InnateDB Protein
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IDBP-26230.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCTPP1
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Protein Name
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dCTP pyrophosphatase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000322524
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InnateDB Gene
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IDBG-26228 (DCTPP1)
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Protein Structure
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Function |
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004518
NTP pyrophosphohydrolase MazG, putative catalytic core
IPR009039
EAR
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PFAM |
PF03819
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H773
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PhosphoSite |
PhosphoSite-Q9H773
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TrEMBL |
H3BPN2
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UniProt Splice Variant |
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Entrez Gene |
79077
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UniGene |
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RefSeq |
NP_077001
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HUGO |
HGNC:28777
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OMIM |
615840
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CCDS |
CCDS10680
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HPRD |
18310
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IMGT |
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EMBL |
AC116348
AF210430
AF212242
AK024843
AY453409
BC001344
CR457335
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GenPept |
AAH01344
AAK14927
AAK48422
AAR26724
BAB15025
CAG33616
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