Version 5.4
Mus musculus Protein: Plcg1
Summary
InnateDB Protein IDBP-262335.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Plcg1
Protein Name phospholipase C, gamma 1
Synonyms AI894140; Cded; Plc-1; Plc-gamma1; Plcg-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000105088
InnateDB Gene IDBG-211621 (Plcg1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 154 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005168 neurotrophin TRKA receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0035254 glutamate receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0050852 T cell receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:97615
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001452 SH3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00017
PF14633
PF00018
PF14604
PF00387
PF00169
PF00036
PF13202
PF13405
PF07653
PF09279
PRINTS PR00360
PR00401
PR00390
PR00452
PIRSF PIRSF000952
SMART SM00239
SM00148
SM00252
SM00326
SM00149
SM00233
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q792T1
UniProt Splice Variant
Entrez Gene 18803
UniGene Mm.486517
RefSeq
MGI ID
MGI Symbol Plcg1
OMIM
CCDS
HPRD
IMGT
EMBL AH007341 AL590389 CH466551
GenPept AAD13798 EDL06292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca