InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HEY1

Summary

InnateDB Protein

IDBP-26241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEY1

Protein Name

hairy/enhancer-of-split related with YRPW motif 1

Synonyms

BHLHb31; CHF2; HERP2; HESR1; hHRT1; HRT-1; OAF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000338272

InnateDB Gene

IDBG-26239 (HEY1)

Protein Structure

UniProt Annotation

Function

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269PubMed:11095750, ECO:0000269PubMed:15485867}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988	protein binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035939	microsatellite binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0002076	osteoblast development
GO:0003184	pulmonary valve morphogenesis
GO:0003190	atrioventricular valve formation
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003203	endocardial cushion morphogenesis
GO:0003208	cardiac ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0009948	anterior/posterior axis specification
GO:0010629	negative regulation of gene expression
GO:0035912	dorsal aorta morphogenesis
GO:0036304	umbilical cord morphogenesis
GO:0045669	positive regulation of osteoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060347	heart trabecula formation
GO:0060411	cardiac septum morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0060840	artery development
GO:0060842	arterial endothelial cell differentiation
GO:0061314	Notch signaling involved in heart development
GO:0071385	cellular response to glucocorticoid stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212	regulation of vasculogenesis