Version 5.4
Mus musculus Protein: Fitm2
Summary
InnateDB Protein IDBP-262431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fitm2
Protein Name fat storage-inducing transmembrane protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000105045
InnateDB Gene IDBG-211884 (Fitm2)
Protein Structure
UniProt Annotation
Function Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269PubMed:18160536}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18160536}; Multi-pass membrane protein {ECO:0000269PubMed:18160536}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in white and brown adipose tissues (at protein level). In the heart, mRNA expression levels do not correlate well with protein levels, suggesting post-transcriptional regulation in this organ. {ECO:0000269PubMed:18160536}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007010 cytoskeleton organization
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010890 positive regulation of sequestering of triglyceride
GO:0022604 regulation of cell morphogenesis
GO:0034389 lipid particle organization
GO:0035356 cellular triglyceride homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:2444508
InterPro IPR019388 Fat storage-inducing transmembrane protein
PFAM PF10261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59266
PhosphoSite PhosphoSite-P59266
TrEMBL
UniProt Splice Variant
Entrez Gene 228859
UniGene Mm.438865
RefSeq NP_775573
MGI ID
MGI Symbol Fitm2
OMIM
CCDS CCDS38315
HPRD
IMGT
EMBL AK040900 AK043244 AK163611 AL591488 BC090994 BC138522 BC138532
GenPept AAH90994 AAI38523 AAI38533 BAC30737 BAC31503 BAE37420 CAM22396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca