Version 5.4
Mus musculus Protein: Fcho2
Summary
InnateDB Protein IDBP-262448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcho2
Protein Name FCH domain only 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000105030
InnateDB Gene IDBG-175957 (Fcho2)
Protein Structure
UniProt Annotation
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269PubMed:21762413, ECO:0000269PubMed:21883765}.
Subcellular Localization Membrane, clathrin-coated pit {ECO:0000305PubMed:20448150, ECO:0000305PubMed:21762413}; Peripheral membrane protein {ECO:0000305PubMed:20448150, ECO:0000305PubMed:21762413}; Cytoplasmic side {ECO:0000305PubMed:20448150, ECO:0000305PubMed:21762413}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2.
Disease Associations
Tissue Specificity Ubiquitously expressed (at protein level). {ECO:0000269PubMed:21762413}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0010324 membrane invagination
GO:0048268 clathrin coat assembly
GO:0072583 clathrin-mediated endocytosis
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030136 clathrin-coated vesicle
Protein Structure and Domains
PDB ID MGI:3505790
InterPro IPR001060 FCH domain
PFAM PF00611
PRINTS
PIRSF
SMART SM00055
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UQN2
PhosphoSite PhosphoSite-Q3UQN2
TrEMBL
UniProt Splice Variant
Entrez Gene 218503
UniGene Mm.398551
RefSeq
MGI ID
MGI Symbol Fcho2
OMIM
CCDS
HPRD
IMGT
EMBL AK031041 AK142282 AK146566 BC052456 BC053718
GenPept AAH52456 AAH53718 BAC27226 BAE25007 BAE27264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca