InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUPT16H

Summary

InnateDB Protein

IDBP-2625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUPT16H

Protein Name

suppressor of Ty 16 homolog (S. cerevisiae)

Synonyms

CDC68; FACTP140; SPT16/CDC68;

Species

Homo sapiens

Ensembl Protein

ENSP00000216297

InnateDB Gene

IDBG-2623 (SUPT16H)

Protein Structure

UniProt Annotation

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. {ECO:0000269PubMed:10912001, ECO:0000269PubMed:11239457, ECO:0000269PubMed:12837248, ECO:0000269PubMed:12934006, ECO:0000269PubMed:16713563, ECO:0000269PubMed:9489704, ECO:0000269PubMed:9836642}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10421373}. Chromosome {ECO:0000269PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10792464}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	103 [view]
Protein-Protein	97 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006337	nucleosome disassembly
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0050434	positive regulation of viral transcription