InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttll8

Summary

InnateDB Protein

IDBP-262530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttll8

Protein Name

tubulin tyrosine ligase-like family, member 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104996

InnateDB Gene

IDBG-171949 (Ttll8)

Protein Structure

UniProt Annotation

Function

Monoglycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. {ECO:0000269PubMed:19427864, ECO:0000269PubMed:19524510}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305PubMed:19524510}. Cell projection, cilium {ECO:0000305PubMed:19524510}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305PubMed:19524510}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in testis. {ECO:0000269PubMed:17499049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016989	sigma factor antagonist activity
GO:0070735	protein-glycine ligase activity
GO:0070736	protein-glycine ligase activity, initiating