InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slpi

Summary

InnateDB Protein

IDBP-262541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slpi

Protein Name

secretory leukocyte peptidase inhibitor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104992

InnateDB Gene

IDBG-212112 (Slpi)

Protein Structure

UniProt Annotation

Function

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression in lung, spleen, intestine and epididymis with lower levels in liver and seminal vesicle. No expression in brain, heart, kidney and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0010951	negative regulation of endopeptidase activity
GO:0032091	negative regulation of protein binding
GO:0045071	negative regulation of viral genome replication