InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nln

Summary

InnateDB Protein

IDBP-262650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nln

Protein Name

neurolysin (metallopeptidase M3 family)

Synonyms

4930472G13Rik; C79345;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104938

InnateDB Gene

IDBG-179540 (Nln)

Protein Structure

UniProt Annotation

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0008150	biological_process

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1923055

InterPro

IPR001567 Peptidase M3A/M3B

PFAM

PF01432

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91YP2

PhosphoSite

PhosphoSite-

TrEMBL

Q3TB65

UniProt Splice Variant

Entrez Gene

75805

UniGene

Mm.127692

RefSeq

NP_083723

MGI ID

MGI Symbol

Nln

OMIM

CCDS

CCDS36772

HPRD

IMGT

EMBL

AK079090 AK146364 AK171432 BC016224 BC025520

GenPept

AAH16224 AAH25520 BAC37533 BAE27114 BAE42449