InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif21a

Summary

InnateDB Protein

IDBP-262698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif21a

Protein Name

kinesin family member 21A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104911

InnateDB Gene

IDBG-175269 (Kif21a)

Protein Structure

UniProt Annotation

Function

Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. {ECO:0000269PubMed:10225949}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:10225949}. Cell projection, dendrite {ECO:0000269PubMed:10225949}. Cell projection, axon {ECO:0000269PubMed:10225949}. Note=In neurons, localized to axons and dendrites.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in brain. {ECO:0000269PubMed:10225949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0030424	axon
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:109188

InterPro

IPR001680 WD40 repeat
IPR001752 Kinesin, motor domain
IPR009053 Prefoldin
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00400
PF00225

PRINTS

PR00380

PIRSF

SMART

SM00320
SM00129

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt