InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pelo

Summary

InnateDB Protein

IDBP-262845.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pelo

Protein Name

pelota homolog (Drosophila)

Synonyms

AA409897; AI852218;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104849

InnateDB Gene

IDBG-184278 (Pelo)

Protein Structure

UniProt Annotation

Function

Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000305}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12438745}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0051276	chromosome organization
GO:0051301	cell division
GO:0070481	nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
GO:0071025	RNA surveillance
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2145154

InterPro

IPR004405 Translation release factor pelota
IPR005140 eRF1 domain 1/Pelota-like
IPR005141 eRF1 domain 2
IPR005142 eRF1 domain 3
IPR029064 50S ribosomal protein L30e-like

PFAM

PF03463
PF03464
PF03465

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80X73

PhosphoSite