InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spo11

Summary

InnateDB Protein

IDBP-263047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spo11

Protein Name

sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)

Synonyms

AI449549;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104754

InnateDB Gene

IDBG-213339 (Spo11)

Protein Structure

UniProt Annotation

Function

Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. {ECO:0000250, ECO:0000269PubMed:22346761}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

High levels are found only in the testis where expression is restricted primarily to meiotic germ cells. Not expressed in spermatogonia. Highest levels are found in pachytene spermatocytes. Very low levels are found in thymus, brain and oocytes of embryonic ovary. Not detected in adult ovary. {ECO:0000269PubMed:10534401, ECO:0000269PubMed:10622720, ECO:0000269PubMed:10855504}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006259	DNA metabolic process
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0034502	protein localization to chromosome

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005654	nucleoplasm
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

MGI:1349669

InterPro

IPR002815 Spo11/DNA topoisomerase VI, subunit A
IPR004084 Meiosis-specific protein Spo11
IPR004085 DNA topoisomerase VI, subunit A
IPR013048 Meiotic recombination, Spo11
IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal

PFAM

PF03533
PF04406

PRINTS

PR01550
PR01552
PR01551

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTK8