InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbp1

Summary

InnateDB Protein

IDBP-263080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbp1

Protein Name

Z-DNA binding protein 1

Synonyms

2010010H03Rik; Dai; Dlm1; mZaDLM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104744

InnateDB Gene

IDBG-213369 (Zbp1)

Protein Structure

UniProt Annotation

Function

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. {ECO:0000269PubMed:17618271, ECO:0000269PubMed:19590578}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in lung, spleen and liver. Lower levels were seen in heart, kidney and testis. Expression is greatly up-regulated in tumor stromal cells and activated macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003692	left-handed Z-DNA binding
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity

Biological Process

GO:0008152	metabolic process
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060340	positive regulation of type I interferon-mediated signaling pathway