Version 5.4
Mus musculus Protein: Gnas
Summary
InnateDB Protein IDBP-263120.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Gnas
Protein Name GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Synonyms 5530400H20Rik; A930027G11Rik; C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gsa; GSP; Nesp; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH;
Species Mus musculus
Ensembl Protein ENSMUSP00000104711
InnateDB Gene IDBG-213434 (Gnas)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031852 mu-type opioid receptor binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0001501 skeletal system development
GO:0001894 tissue homeostasis
GO:0001958 endochondral ossification
GO:0006112 energy reserve metabolic process
GO:0006184 GTP catabolic process
GO:0006306 DNA methylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007606 sensory perception of chemical stimulus
GO:0009791 post-embryonic development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035264 multicellular organism growth
GO:0040032 post-embryonic body morphogenesis
GO:0042493 response to drug
GO:0043588 skin development
GO:0045669 positive regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051216 cartilage development
GO:0071514 genetic imprinting
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0016020 membrane
GO:0030425 dendrite
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Protein Structure and Domains
PDB ID MGI:95777
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00503
PRINTS PR00318
PIRSF
SMART SM00275
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9JJ21
UniProt Splice Variant
Entrez Gene 14683
UniGene Mm.448241
RefSeq
MGI ID
MGI Symbol Gnas
OMIM
CCDS
HPRD
IMGT
EMBL AF152375 AL593857 L27661
GenPept AAA37718 AAF89525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca