Version 5.4
Mus musculus Protein: Sec24a
Summary
InnateDB Protein IDBP-263129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec24a
Protein Name Sec24 related gene family, member A (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104725
InnateDB Gene IDBG-170393 (Sec24a)
Protein Structure
UniProt Annotation
Function Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050714 positive regulation of protein secretion
GO:2000189 positive regulation of cholesterol homeostasis
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0030127 COPII vesicle coat
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1924621
InterPro IPR002035 von Willebrand factor, type A
IPR006895 Zinc finger, Sec23/Sec24-type
IPR006896 Sec23/Sec24, trunk domain
IPR006900 Sec23/Sec24, helical domain
IPR007123 Gelsolin-like domain
IPR012990 Sec23/Sec24 beta-sandwich
PFAM PF00092
PF04810
PF04811
PF04815
PF00626
PF08033
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U2P1
PhosphoSite PhosphoSite-Q3U2P1
TrEMBL Q8BJ88
UniProt Splice Variant
Entrez Gene 77371
UniGene Mm.417027
RefSeq NP_780464
MGI ID
MGI Symbol Sec24a
OMIM
CCDS CCDS24660
HPRD
IMGT
EMBL AK029139 AK090341 AK155182 AK162795 AK163998 AL645602 BC117905
GenPept AAI17906 BAC26319 BAC41177 BAE33099 BAE37062 BAE37580 CAM26935 CAM26938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca