InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcbp2

Summary

InnateDB Protein

IDBP-263683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcbp2

Protein Name

poly(rC) binding protein 2

Synonyms

alphaCP-2; AW412548; Hnrpx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104466

InnateDB Gene

IDBG-188762 (Pcbp2)

Protein Structure

UniProt Annotation

Function

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050687	negative regulation of defense response to virus
GO:0051607	defense response to virus