Mus musculus Protein: Hist3h2a
Summary
InnateDB Protein IDBP-263739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist3h2a
Protein Name histone cluster 3, H2a
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104445
InnateDB Gene IDBG-263737 (Hist3h2a)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2448458
InterPro IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFU2
PhosphoSite PhosphoSite-Q8BFU2
TrEMBL A2AB79
UniProt Splice Variant
Entrez Gene 319162
UniGene Mm.460331
RefSeq NP_835736
MGI ID
MGI Symbol Hist3h2a
OMIM
CCDS CCDS24755
HPRD
IMGT
EMBL AK051448 AK077568 AK083155 AK087537 AY158926 BC058119 BC063781 CH466628
GenPept AAH58119 AAH63781 AAO06236 BAC34643 BAC36868 BAC38786 BAC39917 EDL07697