InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zgpat

Summary

InnateDB Protein

IDBP-263749.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zgpat

Protein Name

zinc finger, CCCH-type with G patch domain

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104435

InnateDB Gene

IDBG-214086 (Zgpat)

Protein Structure

UniProt Annotation

Function

Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0045892	negative regulation of transcription, DNA-templated