Version 5.4
Mus musculus Protein: Gjc2
Summary
InnateDB Protein IDBP-263781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gjc2
Protein Name gap junction protein, gamma 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104421
InnateDB Gene IDBG-178307 (Gjc2)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. {ECO:0000269PubMed:11160382, ECO:0000269PubMed:12843301}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15183511}; Multi-pass membrane protein {ECO:0000269PubMed:15183511}. Cell junction, gap junction {ECO:0000269PubMed:15183511}.
Disease Associations
Tissue Specificity Mainly expressed by oligodendrocytes in the central nervous system (at protein level). {ECO:0000269PubMed:12805295, ECO:0000269PubMed:12843301, ECO:0000269PubMed:15183511}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
Biological Process
GO:0007267 cell-cell signaling
GO:0009636 response to toxic substance
GO:0055085 transmembrane transport
Cellular Component
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
GO:0043209 myelin sheath
Protein Structure and Domains
PDB ID MGI:2153060
InterPro IPR000500 Connexin
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BQU6
PhosphoSite PhosphoSite-Q8BQU6
TrEMBL
UniProt Splice Variant
Entrez Gene 118454
UniGene Mm.40016
RefSeq NP_780661
MGI ID
MGI Symbol Gjc2
OMIM
CCDS CCDS24760
HPRD
IMGT
EMBL AJ276435 AK046421 AK046609 AY394498 AY394499 AY394500
GenPept AAR05823 AAR05824 AAR05825 BAC32722 BAC32806 CAC19434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca