InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP5O

Summary

InnateDB Protein

IDBP-2638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5O

Protein Name

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Synonyms

ATPO; OSCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000290299

InnateDB Gene

IDBG-401918 (ATP5O)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subcellular Localization

Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008144	drug binding
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0006754	ATP biosynthetic process
GO:0015986	ATP synthesis coupled proton transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome