Version 5.4
Mus musculus Protein: Mprip
Summary
InnateDB Protein IDBP-263860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mprip
Protein Name myosin phosphatase Rho interacting protein
Synonyms 9530046C02; AA536749; AI647711; C76423; mKIAA0864; p116Rip; Rhoip3; RIP3;
Species Mus musculus
Ensembl Protein ENSMUSP00000104382
InnateDB Gene IDBG-179147 (Mprip)
Protein Structure
UniProt Annotation
Function Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000269PubMed:12732640, ECO:0000269PubMed:15469989}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:12732640}. Note=Colocalizes with F-actin.
Disease Associations
Tissue Specificity Expressed in Kidney, Brain, Heart and Lung. {ECO:0000269PubMed:9199174}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1349438
InterPro IPR001849 Pleckstrin homology domain
IPR009078 Ferritin-like superfamily
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97434
PhosphoSite PhosphoSite-P97434
TrEMBL
UniProt Splice Variant
Entrez Gene 26936
UniGene Mm.327678
RefSeq
MGI ID
MGI Symbol Mprip
OMIM
CCDS
HPRD
IMGT
EMBL AK154807 AK155630 AK158296 AK162530 AK170849 AK171089 AL596204 BC049803 BC063067 U73200
GenPept AAB18198 AAH49803 AAH63067 BAE32843 BAE33355 BAE34450 BAE36957 BAE42072 BAE42242 CAI24300 CAI24303 CAI24304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca