InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrp12

Summary

InnateDB Protein

IDBP-264085.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp12

Protein Name

NLR family, pyrin domain containing 12

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104293

InnateDB Gene

IDBG-264083 (Nlrp12)

Protein Structure

UniProt Annotation

Function

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0009968	negative regulation of signal transduction
GO:0031953	negative regulation of protein autophosphorylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0036336	dendritic cell migration
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045751	negative regulation of Toll signaling pathway
GO:0050710	negative regulation of cytokine secretion
GO:0050711	negative regulation of interleukin-1 secretion
GO:0050728	negative regulation of inflammatory response
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071345	cellular response to cytokine stimulus
GO:1901223	negative regulation of NIK/NF-kappaB signaling

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:2676630

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

E9Q5R7