InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlgn2

Summary

InnateDB Protein

IDBP-264120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlgn2

Protein Name

neuroligin 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104274

InnateDB Gene

IDBG-192156 (Nlgn2)

Protein Structure

UniProt Annotation

Function

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. {ECO:0000250, ECO:0000269PubMed:10892652, ECO:0000269PubMed:15620359, ECO:0000269PubMed:16982420, ECO:0000269PubMed:19553444, ECO:0000269PubMed:19889999, ECO:0000269PubMed:20530218}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}. Cell junction, synapse, presynaptic cell membrane. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain and arteries. Detected in the retina outer plexiform layer (at protein level). Widely expressed. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:16982420, ECO:0000269PubMed:18434543, ECO:0000269PubMed:19755106, ECO:0000269PubMed:19859968, ECO:0000269PubMed:19926856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0042043	neurexin family protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001966	thigmotaxis
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0007158	neuron cell-cell adhesion
GO:0007416	synapse assembly
GO:0007630	jump response
GO:0008152	metabolic process
GO:0019233	sensory perception of pain
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0035641	locomotory exploration behavior
GO:0050804	regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0072553	terminal button organization
GO:0097104	postsynaptic membrane assembly
GO:0097105	presynaptic membrane assembly
GO:0097116	gephyrin clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097151	positive regulation of inhibitory postsynaptic membrane potential
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0060077	inhibitory synapse