InnateDB Protein
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IDBP-264123.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plscr3
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Protein Name
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phospholipid scramblase 3
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Synonyms
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2210403O21Rik; 2610037N06Rik; ESTM3; X83310;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104273
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InnateDB Gene
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IDBG-192229 (Plscr3)
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Protein Structure
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Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. {ECO:0000269PubMed:19428821}.
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Subcellular Localization |
Mitochondrion membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917560
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InterPro |
IPR005552
Scramblase
IPR025659
Tubby C-terminal-like domain
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PFAM |
PF03803
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JIZ9
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PhosphoSite |
PhosphoSite-Q9JIZ9
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TrEMBL |
Q5F284
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UniProt Splice Variant |
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Entrez Gene |
70310
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UniGene |
Mm.28874
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RefSeq |
NP_076053
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MGI ID |
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MGI Symbol |
Plscr3
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OMIM |
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CCDS |
CCDS24916
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HPRD |
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IMGT |
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EMBL |
AF159850
AK011716
AK029154
AK075841
AK166288
AL603707
BC020143
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GenPept |
AAF89526
AAH20143
BAB27797
BAC26329
BAC35999
BAE38684
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