Version 5.4
Mus musculus Protein: Plscr3
Summary
InnateDB Protein IDBP-264125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plscr3
Protein Name phospholipid scramblase 3
Synonyms 2210403O21Rik; 2610037N06Rik; ESTM3; X83310;
Species Mus musculus
Ensembl Protein ENSMUSP00000104272
InnateDB Gene IDBG-192229 (Plscr3)
Protein Structure
UniProt Annotation
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. {ECO:0000269PubMed:19428821}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006915 apoptotic process
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:1917560
InterPro IPR005552 Scramblase
IPR025659 Tubby C-terminal-like domain
PFAM PF03803
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JIZ9
PhosphoSite PhosphoSite-Q9JIZ9
TrEMBL Q5F284
UniProt Splice Variant
Entrez Gene 70310
UniGene Mm.28874
RefSeq NP_001161969
MGI ID
MGI Symbol Plscr3
OMIM
CCDS CCDS24916
HPRD
IMGT
EMBL AF159850 AK011716 AK029154 AK075841 AK166288 AL603707 BC020143
GenPept AAF89526 AAH20143 BAB27797 BAC26329 BAC35999 BAE38684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca