Version 5.4
Mus musculus Protein: Elp5
Summary
InnateDB Protein IDBP-264204.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elp5
Protein Name retinoic acid induced 12
Synonyms Derp6; Rai12;
Species Mus musculus
Ensembl Protein ENSMUSP00000104235
InnateDB Gene IDBG-192975 (Elp5)
Protein Structure
UniProt Annotation
Function Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May be involved in TP53-mediated transcriptional regulation. Involved in cell migration. {ECO:0000269PubMed:22854966}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in testis. {ECO:0000269PubMed:9371513}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030335 positive regulation of cell migration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0033588 Elongator holoenzyme complex
Protein Structure and Domains
PDB ID MGI:1859017
InterPro IPR019519 Elongator complex protein 5
PFAM PF10483
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99L85
PhosphoSite PhosphoSite-Q99L85
TrEMBL J3QMW4
UniProt Splice Variant
Entrez Gene 54351
UniGene Mm.13430
RefSeq NP_061210
MGI ID
MGI Symbol Elp5
OMIM
CCDS CCDS24926
HPRD
IMGT
EMBL AF004107 AK013662 AK152582 AL596185 BC003752
GenPept AAC16252 AAH03752 BAB28944 BAE31332 CAI35160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca