InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dact3

Summary

InnateDB Protein

IDBP-264422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dact3

Protein Name

dapper homolog 3, antagonist of beta-catenin (xenopus)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104133

InnateDB Gene

IDBG-264420 (Dact3)

Protein Structure

UniProt Annotation

Function

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain and uterus. {ECO:0000269PubMed:16881060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051018	protein kinase A binding
GO:0070097	delta-catenin binding

Biological Process

GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0035414	negative regulation of catenin import into nucleus
GO:0090090	negative regulation of canonical Wnt signaling pathway