Version 5.4
Mus musculus Protein: Ctns
Summary
InnateDB Protein IDBP-264467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctns
Protein Name cystinosis, nephropathic
Synonyms AI195360; AW049661;
Species Mus musculus
Ensembl Protein ENSMUSP00000104116
InnateDB Gene IDBG-197973 (Ctns)
Protein Structure
UniProt Annotation
Function Thought to transport cystine out of lysosomes.
Subcellular Localization Lysosome membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015184 L-cystine transmembrane transporter activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006749 glutathione metabolic process
GO:0007420 brain development
GO:0007616 long-term memory
GO:0007625 grooming behavior
GO:0007628 adult walking behavior
GO:0008542 visual learning
GO:0015811 L-cystine transport
GO:0046034 ATP metabolic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1932872
InterPro IPR005282 Lysosomal cystine transporter
IPR006603 PQ-loop repeat
PFAM PF04193
PRINTS
PIRSF
SMART SM00679
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57757
PhosphoSite PhosphoSite-
TrEMBL Q542U5
UniProt Splice Variant
Entrez Gene 83429
UniGene Mm.259852
RefSeq XP_006534596
MGI ID
MGI Symbol Ctns
OMIM
CCDS CCDS25001
HPRD
IMGT
EMBL AJ250670 AK054467 AK078511 AK079295 AK137143 AK170790 BC005479 CH466596
GenPept AAH05479 BAC35789 BAC37316 BAC37598 BAE23249 BAE42030 CAC19455 EDL12715 EDL12716

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca