InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klc3

Summary

InnateDB Protein

IDBP-264495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klc3

Protein Name

kinesin light chain 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104098

InnateDB Gene

IDBG-150559 (Klc3)

Protein Structure

UniProt Annotation

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305PubMed:11319135}. Note=Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in postmeiotic male germ cells (at protein level). Expressed in spleen, intestine, brain, ovary, testis, spermatocytes and spermatids. {ECO:0000269PubMed:11319135}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019894	kinesin binding

Biological Process

GO:0008088	axon cargo transport
GO:0008152	metabolic process
GO:0042073	intraciliary transport

Cellular Component

GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0031514	motile cilium
GO:0035253	ciliary rootlet
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:1277971

InterPro

IPR001440 Tetratricopeptide TPR1
IPR002151 Kinesin light chain
IPR013026 Tetratricopeptide repeat-containing domain
IPR015390 Rabaptin, GTPase-Rab5 binding domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF09311
PF13174
PF13176
PF13181

PRINTS

PR00381

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt