InnateDB Protein
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IDBP-264651.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pag1
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Protein Name
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phosphoprotein associated with glycosphingolipid microdomains 1
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Synonyms
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Cbp; F730007C19Rik; Pag;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104021
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InnateDB Gene
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IDBG-131044 (Pag1)
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Protein Structure
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Function |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269PubMed:12218089, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11777944, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}; Single-pass type III membrane protein {ECO:0000269PubMed:11777944, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}. Note=Present in lipid rafts.
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Disease Associations |
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Tissue Specificity |
Present in T-cells (at protein level). {ECO:0000269PubMed:16166631}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443160
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U1F9
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PhosphoSite |
PhosphoSite-Q3U1F9
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TrEMBL |
A6H659
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UniProt Splice Variant |
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Entrez Gene |
94212
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UniGene |
Mm.486503
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RefSeq |
NP_444412
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MGI ID |
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MGI Symbol |
Pag1
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OMIM |
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CCDS |
CCDS17235
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HPRD |
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IMGT |
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EMBL |
AF250192
AK040230
AK089329
AK156000
AK172106
BC145328
BC145761
BC145763
CH466577
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GenPept |
AAG44565
AAI45329
AAI45762
AAI45764
BAC30545
BAC40842
BAE33539
BAE42829
EDL05179
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