Version 5.4
Mus musculus Protein: Hipk4
Summary
InnateDB Protein IDBP-264726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hipk4
Protein Name homeodomain interacting protein kinase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103990
InnateDB Gene IDBG-161259 (Hipk4)
Protein Structure
UniProt Annotation
Function Protein kinase that phosphorylates murine TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). {ECO:0000305}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18022393}.
Disease Associations
Tissue Specificity Expressed at moderate levels in lung and white adipose tissues and weakly in brain and liver. {ECO:0000269PubMed:18022393}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0046777 protein autophosphorylation
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2685008
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3V016
PhosphoSite PhosphoSite-Q3V016
TrEMBL
UniProt Splice Variant
Entrez Gene 233020
UniGene Mm.429716
RefSeq NP_001028487
MGI ID
MGI Symbol Hipk4
OMIM
CCDS CCDS21024
HPRD
IMGT
EMBL AB354583 AC158304 AK133498 BC147572 BC147577
GenPept AAI47573 AAI47578 BAE21689 BAF93448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca