InnateDB Protein
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IDBP-264806.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Esrp1
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Protein Name
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epithelial splicing regulatory protein 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103949
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InnateDB Gene
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IDBG-129461 (Esrp1)
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Protein Structure
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Function |
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Epithelial cell-specific. Epithelial-specific expression in diverse tissues and organs with particularly notable levels of expression in skin and gastrointestinal epithelia. {ECO:0000269PubMed:19285943}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917326
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InterPro |
IPR000504
RNA recognition motif domain
IPR012337
Ribonuclease H-like domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q3US41
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
207920
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UniGene |
Mm.387719
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RefSeq |
XP_006537781
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MGI ID |
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MGI Symbol |
Esrp1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK042164
AK140848
AK166376
AL772170
BC031468
BC059280
CH466538
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GenPept |
AAH31468
AAH59280
BAC31189
BAE24496
BAE38739
CAM20812
CAM20813
CAM20814
CAM20815
CAM20816
EDL05650
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