Version 5.4
Mus musculus Protein: Esrp1
Summary
InnateDB Protein IDBP-264812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Esrp1
Protein Name epithelial splicing regulatory protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103946
InnateDB Gene IDBG-129461 (Esrp1)
Protein Structure
UniProt Annotation
Function mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Epithelial cell-specific. Epithelial-specific expression in diverse tissues and organs with particularly notable levels of expression in skin and gastrointestinal epithelia. {ECO:0000269PubMed:19285943}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1917326
InterPro IPR000504 RNA recognition motif domain
IPR012337 Ribonuclease H-like domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3US41
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 207920
UniGene Mm.387719
RefSeq
MGI ID
MGI Symbol Esrp1
OMIM
CCDS
HPRD
IMGT
EMBL AK042164 AK140848 AK166376 AL772170 BC031468 BC059280 CH466538
GenPept AAH31468 AAH59280 BAC31189 BAE24496 BAE38739 CAM20812 CAM20813 CAM20814 CAM20815 CAM20816 EDL05650

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca