Version 5.4
Homo sapiens Protein: GORASP1
Summary
InnateDB Protein IDBP-26485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GORASP1
Protein Name golgi reassembly stacking protein 1, 65kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000313869
InnateDB Gene IDBG-26483 (GORASP1)
Protein Structure
UniProt Annotation
Function Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes.
Subcellular Localization Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:11706049}; Peripheral membrane protein {ECO:0000269PubMed:11706049}; Cytoplasmic side {ECO:0000269PubMed:11706049}. Note=Undergoes rapid exchange with the cytosol.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007030 Golgi organization
GO:0015031 protein transport
GO:0050774 negative regulation of dendrite morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR024958 GRASP55/65 PDZ-like domain
PFAM PF00595
PF13180
PF04495
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQQ3
PhosphoSite PhosphoSite-Q9BQQ3
TrEMBL F8WD30
UniProt Splice Variant
Entrez Gene 64689
UniGene Hs.721946
RefSeq NP_114105
HUGO HGNC:16769
OMIM 606867
CCDS CCDS2681
HPRD 06038
IMGT
EMBL AC138124 AJ409349 AK091168 AK124755 BC008928 BC075854 BC103826 BC103827 CH471055
GenPept AAH08928 AAH75854 AAI03827 AAI03828 BAC03598 BAG54090 CAC35160 EAW64554 EAW64559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca