InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sarm1

Summary

InnateDB Protein

IDBP-264860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sarm1

Protein Name

sterile alpha and HEAT/Armadillo motif containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103922

InnateDB Gene

IDBG-202876 (Sarm1)

Protein Structure

UniProt Annotation

Function

Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent activation of NF- kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis. {ECO:0000269PubMed:17724133, ECO:0000269PubMed:19587044, ECO:0000269PubMed:21555464, ECO:0000269PubMed:22678360}.

Subcellular Localization

Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Note=Associated with microtubules.

Disease Associations

Tissue Specificity

Widely expressed in the brain and neurons (at protein level). {ECO:0000269PubMed:21555464}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0009749	response to glucose
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0048814	regulation of dendrite morphogenesis
GO:1901214	regulation of neuron death

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031315	extrinsic component of mitochondrial outer membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:2136419

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016024 Armadillo-type fold
IPR021129 Sterile alpha motif, type 1

PFAM

PF01582
PF13676
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00255
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PDS3