InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RY11

Summary

InnateDB Protein

IDBP-26488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY11

Protein Name

purinergic receptor P2Y, G-protein coupled, 11

Synonyms

P2Y11;

Species

Homo sapiens

Ensembl Protein

ENSP00000323872

InnateDB Gene

IDBG-409054 (P2RY11)

Protein Structure

UniProt Annotation

Function

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest expression in liver and spleen. {ECO:0000269PubMed:11278528}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0030594	neurotransmitter receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045031	ATP-activated nucleotide receptor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0006952	defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0019722	calcium-mediated signaling
GO:0023041	neuronal signal transduction
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0071318	cellular response to ATP