Version 5.4
Mus musculus Protein: Mms22l
Summary
InnateDB Protein IDBP-264994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mms22l
Protein Name MMS22-like, DNA repair protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103857
InnateDB Gene IDBG-132170 (Mms22l)
Protein Structure
UniProt Annotation
Function Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0031297 replication fork processing
Cellular Component
GO:0035101 FACT complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
Protein Structure and Domains
PDB ID MGI:2684980
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B1AUR6
PhosphoSite PhosphoSite-B1AUR6
TrEMBL
UniProt Splice Variant
Entrez Gene 212377
UniGene Mm.452104
RefSeq NP_955761
MGI ID
MGI Symbol Mms22l
OMIM
CCDS CCDS18006
HPRD
IMGT
EMBL AL671913 AY512923 BC051674 BC137910 BC145028 BX296536
GenPept AAH51674 AAI37911 AAI45029 AAR87794 CAM23327

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca