Version 5.4
Mus musculus Protein: Dcun1d1
Summary
InnateDB Protein IDBP-265077.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcun1d1
Protein Name DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103817
InnateDB Gene IDBG-138119 (Dcun1d1)
Protein Structure
UniProt Annotation
Function Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic in vivo. {ECO:0000269PubMed:20563250}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in testis. Also expressed in brain, heart, liver, skeletal muscle and kidney. In brain, preferentially expressed in the telencephalon ventricular and subventricular zones, albeit at low levels. In adult testis, expressed in cells above seminiferous tubules, but only weakly in spermatogonia. {ECO:0000269PubMed:10777668, ECO:0000269PubMed:10831844}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 198 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 198 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0000151 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:2150386
InterPro IPR005176 Potentiating neddylation domain
IPR009060 UBA-like
PFAM PF03556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZ73
PhosphoSite PhosphoSite-Q9QZ73
TrEMBL Q3UT23
UniProt Splice Variant
Entrez Gene 114893
UniGene Mm.488396
RefSeq NP_001192290
MGI ID
MGI Symbol Dcun1d1
OMIM
CCDS CCDS57207
HPRD
IMGT
EMBL AC116677 AF198092 AK008657 AK029314 AK139845 AK155081 AK165651 BC020161 BC031666 BC037431
GenPept AAF04863 AAH20161 AAH31666 AAH37431 BAB25813 BAC26390 BAE24157 BAE33033 BAE38318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca