InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfkbid

Summary

InnateDB Protein

IDBP-265091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfkbid

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103811

InnateDB Gene

IDBG-168861 (Nfkbid)

Protein Structure

UniProt Annotation

Function

May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes. {ECO:0000269PubMed:11931770, ECO:0000269PubMed:15749903, ECO:0000269PubMed:16410444, ECO:0000269PubMed:16413922, ECO:0000269PubMed:17641034}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11931770}.

Disease Associations

Tissue Specificity

Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response. {ECO:0000269PubMed:11931770, ECO:0000269PubMed:16410444}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006954	inflammatory response
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070245	positive regulation of thymocyte apoptotic process