InnateDB Protein
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IDBP-265097.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rffl
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Protein Name
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ring finger and FYVE like domain containing protein
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Synonyms
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1700051E09Rik; 4930516L10Rik; BG080975; Carp2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103808
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InnateDB Gene
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IDBG-204769 (Rffl)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SNF. May also play a role in endocytic recycling. {ECO:0000269PubMed:15229288, ECO:0000269PubMed:22609986}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:15229288}. Cell membrane {ECO:0000269PubMed:15229288}; Peripheral membrane protein {ECO:0000269PubMed:15229288}. Recycling endosome membrane {ECO:0000305PubMed:15229288}; Peripheral membrane protein {ECO:0000305PubMed:15229288}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis, thymus, whole embryo and embryonic stem cells. {ECO:0000269PubMed:15229288}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0006886
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intracellular protein transport
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GO:0010762
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regulation of fibroblast migration
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GO:0010804
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negative regulation of tumor necrosis factor-mediated signaling pathway
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0070936
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protein K48-linked ubiquitination
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GO:1901797
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negative regulation of signal transduction by p53 class mediator
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:2001271
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negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
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Cellular Component |
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PDB ID |
MGI:1914588
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InterPro |
IPR001841
Zinc finger, RING-type
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZQM0
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PhosphoSite |
PhosphoSite-Q6ZQM0
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TrEMBL |
Q6YAT6
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UniProt Splice Variant |
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Entrez Gene |
67338
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UniGene |
Mm.341608
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RefSeq |
NP_001007466
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MGI ID |
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MGI Symbol |
Rffl
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OMIM |
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CCDS |
CCDS25148
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HPRD |
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IMGT |
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EMBL |
AF434814
AK007189
AK015806
AK028095
AK128983
AK150213
AL645594
AY163902
AY163903
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GenPept |
AAL30769
AAO42677
AAO42678
BAB24891
BAB29984
BAC25744
BAC87665
BAE29383
CAI25096
CAI25097
CAI25098
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