Mus musculus Protein: Unc45b
Summary
InnateDB Protein IDBP-265121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc45b
Protein Name unc-45 homolog B (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103795
InnateDB Gene IDBG-205012 (Unc45b)
Protein Structure
UniProt Annotation
Function Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. {ECO:0000269PubMed:12356907, ECO:0000269PubMed:18326487, ECO:0000269PubMed:18478096}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:18478096}.
Disease Associations
Tissue Specificity Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart. {ECO:0000269PubMed:12356907}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0030154 cell differentiation
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2443377
InterPro IPR000225 Armadillo
IPR013026 Tetratricopeptide repeat-containing domain
IPR016024 Armadillo-type fold
IPR019734 Tetratricopeptide repeat
IPR024660 UNC-45/Ring assembly protein 3
PFAM PF00514
PF13174
PF13176
PF13181
PF11701
PRINTS
PIRSF
SMART SM00185
SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CGY6
PhosphoSite PhosphoSite-Q8CGY6
TrEMBL
UniProt Splice Variant
Entrez Gene 217012
UniGene Mm.295205
RefSeq
MGI ID
MGI Symbol Unc45b
OMIM
CCDS
HPRD
IMGT
EMBL AF539793 AK052294 AK081821 AK084418 AL603745 BC084585
GenPept AAH84585 AAO13383 BAC34921 BAC38342 BAC39178 CAI25496