InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rngtt

Summary

InnateDB Protein

IDBP-265136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rngtt

Protein Name

RNA guanylyltransferase and 5'-phosphatase

Synonyms

AU020997;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103788

InnateDB Gene

IDBG-134608 (Rngtt)

Protein Structure

UniProt Annotation

Function

Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269PubMed:21683636, ECO:0000269PubMed:9371772}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004484	mRNA guanylyltransferase activity
GO:0004651	polynucleotide 5'-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005525	GTP binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008192	RNA guanylyltransferase activity
GO:0016791	phosphatase activity
GO:0050355	triphosphatase activity

Biological Process

GO:0006370	7-methylguanosine mRNA capping
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0098507	polynucleotide 5' dephosphorylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1329041

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001339 mRNA capping enzyme
IPR012340 Nucleic acid-binding, OB-fold
IPR013846 mRNA capping enzyme, C-terminal
IPR017074 mRNA capping enzyme, bifunctional
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF01331
PF03919

PRINTS

PR00700

PIRSF

PIRSF036958

SMART

SM00194

TIGRFAMs

Post-translational Modifications

Modification

Cross-References