InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbtb32

Summary

InnateDB Protein

IDBP-265142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbtb32

Protein Name

zinc finger and BTB domain containing 32

Synonyms

4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103785

InnateDB Gene

IDBG-170534 (Zbtb32)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells. {ECO:0000250, ECO:0000269PubMed:11279021}.

Subcellular Localization

Nucleus. Note=Located in nuclear speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is testis-specific and is not expressed in lymphoid organs such as thymus or spleen. Isoform 2 is expressed in both B-and T-lymphoid cells. {ECO:0000269PubMed:10755619}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0008270	zinc ion binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030097	hemopoiesis
GO:0042098	T cell proliferation

Cellular Component

GO:0000228

nuclear chromosome

Protein Structure and Domains

PDB ID

MGI:1891838

InterPro

IPR015880 Zinc finger, C2H2-like

PFAM

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JKD9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

58206

UniGene

Mm.452815

RefSeq

MGI ID

2KVH

MGI Symbol

Zbtb32

OMIM

CCDS

HPRD

IMGT

EMBL

AF241232 AK015881 AY015272

GenPept

AAF61244 AAK13198 BAB30015