InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASEH1

Summary

InnateDB Protein

IDBP-26516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASEH1

Protein Name

ribonuclease H1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313350

InnateDB Gene

IDBG-26514 (RNASEH1)

Protein Structure

UniProt Annotation

Function

Endonuclease that specifically degrades the RNA of RNA- DNA hybrids.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004523	RNA-DNA hybrid ribonuclease activity
GO:0004540	ribonuclease activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006264	mitochondrial DNA replication
GO:0006401	RNA catabolic process
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR002156 Ribonuclease H domain
IPR009027 Ribosomal protein L9/RNase H1, N-terminal
IPR011320 Ribonuclease H1, N-terminal
IPR012337 Ribonuclease H-like domain
IPR017067 Ribonuclease H1, eukaryote

PFAM

PF00075
PF01693

PRINTS

PIRSF

PIRSF036852

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60930