Version 5.4
Mus musculus Protein: Fgf2
Summary
InnateDB Protein IDBP-265205.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Fgf2
Protein Name fibroblast growth factor 2
Synonyms bFGF; Fgf-2; Fgfb;
Species Mus musculus
Ensembl Protein ENSMUSP00000103755
InnateDB Gene IDBG-140464 (Fgf2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001525 angiogenesis
GO:0001759 organ induction
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010001 glial cell differentiation
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0021762 substantia nigra development
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030324 lung development
GO:0042660 positive regulation of cell fate specification
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046668 regulation of retinal cell programmed cell death
GO:0048678 response to axon injury
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051726 regulation of cell cycle
GO:0051897 positive regulation of protein kinase B signaling
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060644 mammary gland epithelial cell differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:95516
InterPro IPR002209 Fibroblast growth factor family
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family
PFAM
PRINTS PR00263
PR00262
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q925A1
UniProt Splice Variant
Entrez Gene 14173
UniGene Mm.473689
RefSeq
MGI ID
MGI Symbol Fgf2
OMIM
CCDS
HPRD
IMGT
EMBL AL669927 AL691478 AY027558 CH466530
GenPept AAK52310 EDL35108

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca