InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spata5

Summary

InnateDB Protein

IDBP-265223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spata5

Protein Name

spermatogenesis associated 5

Synonyms

2510048F20Rik; C78064; Spaf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103747

InnateDB Gene

IDBG-140658 (Spata5)

Protein Structure

UniProt Annotation

Function

May be involved in morphological and functional mitochondrial transformations during spermatogenesis. {ECO:0000269PubMed:10734318}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10734318}. Mitochondrion {ECO:0000269PubMed:10734318}.

Disease Associations

Tissue Specificity

Expressed in testis; with localization to spermatogonia and early spermatocytes in the basal compartment of the seminiferous tubules (at early stages of spermatogenesis). Very weak signals observed in spleen and skin. {ECO:0000269PubMed:10734318}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0030154	cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1927170

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR009010 Aspartate decarboxylase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UMC0