InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa4l

Summary

InnateDB Protein

IDBP-265254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa4l

Protein Name

heat shock protein 4 like

Synonyms

94kDa; AI461691; APG-1; Osp94;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103721

InnateDB Gene

IDBG-141291 (Hspa4l)

Protein Structure

UniProt Annotation

Function

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis. Also expressed in renal medulla of water-restricted animals. {ECO:0000269PubMed:8647834}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006457	protein folding
GO:0006986	response to unfolded protein

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:107422

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48722