Version 5.4
Mus musculus Protein: Pigw
Summary
InnateDB Protein IDBP-265295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigw
Protein Name phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms 2610044A17Rik; Gwt1;
Species Mus musculus
Ensembl Protein ENSMUSP00000103715
InnateDB Gene IDBG-206416 (Pigw)
Protein Structure
UniProt Annotation
Function Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006506 GPI anchor biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1917575
InterPro IPR009447 GWT1
PFAM PF06423
PRINTS
PIRSF PIRSF017321
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C398
PhosphoSite PhosphoSite-
TrEMBL B7ZN11
UniProt Splice Variant
Entrez Gene 70325
UniGene Mm.390414
RefSeq NP_001071104
MGI ID
MGI Symbol Pigw
OMIM
CCDS CCDS36263
HPRD
IMGT
EMBL AK011762 AK081337 AK086537 AL645623 BC144942 CH466556
GenPept AAI44943 BAB27826 BAC38199 BAC39687 CAI25488 EDL15746 EDL15747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca