InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubap1

Summary

InnateDB Protein

IDBP-265342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubap1

Protein Name

ubiquitin-associated protein 1

Synonyms

2700092A01Rik; NAG20; Ubap; UBAP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103695

InnateDB Gene

IDBG-137683 (Ubap1)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endosome {ECO:0000250}. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in heart, liver, brain, kidney, spleen, skeletal muscle, stomach, testis and lung. {ECO:0000269PubMed:11599797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043130	ubiquitin binding

Biological Process

GO:0015031	protein transport
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Cellular Component

GO:0000813	ESCRT I complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:2149543

InterPro

IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

PFAM

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BH48

PhosphoSite

PhosphoSite-Q8BH48

TrEMBL

UniProt Splice Variant

Entrez Gene

67123

UniGene

Mm.466320

RefSeq

NP_001277383

MGI ID

MGI Symbol

Ubap1

OMIM

CCDS

CCDS71361

HPRD

IMGT

EMBL

AF275549 AK009596 AK028477 AK028670 AK030370 AK033121 AK051346 AK076078 BC065996

GenPept

AAG09810 AAH65996 BAB26382 BAC25970 BAC26057 BAC26927 BAC28160 BAC34609 BAC36165