InnateDB Protein
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IDBP-265350.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Elf2
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Protein Name
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E74-like factor 2
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Synonyms
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2610036A20Rik; A230104O07Rik; AW111824; BB183398; EU32; NERF; NERF-1A; NERF-1B; NERF-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103688
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InnateDB Gene
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IDBG-142712 (Elf2)
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Protein Structure
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Function |
Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues examined. Highest levels in thymocytes and bone marrow. {ECO:0000269PubMed:9001422}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:1916507
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InterPro |
IPR000418
Ets domain
IPR022084
Transcription factor Elf, N-terminal
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PFAM |
PF00178
PF12310
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JHC9
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PhosphoSite |
PhosphoSite-Q9JHC9
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TrEMBL |
Q3UZ20
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UniProt Splice Variant |
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Entrez Gene |
69257
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UniGene |
Mm.131038
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RefSeq |
NP_001277992
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MGI ID |
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MGI Symbol |
Elf2
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OMIM |
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CCDS |
CCDS71241
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HPRD |
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IMGT |
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EMBL |
AF256216
AF256217
AF256218
AF256219
AK088422
AK134180
BC069901
D26064
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GenPept |
AAF67191
AAF67192
AAF67193
AAF67194
AAH69901
BAC40346
BAE22041
BAF93847
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